Global Pediatric Endocrinology & Diabetes

(GPED)

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Vancouver BC V5Z 4R3

Canada

info@globalpedendo.org

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Newsletter

WHO Growth Curves Continued: 

The characteristics of the curves include:

· Use of percentiles

· Metric system (kg, cm) and US system (inches and pounds)

· Length/height for age and weight for age are present on the chart

· Weight for age curves are include for boys and girls older than 10 years.  These data are presently not available on the charts proposed online by the WHO. Most health professionals agree that BMI is the easiest and most recognized marker to evaluate body mass, in particular during puberty, when weight changes are closely linked to pubertal development. However, many health professionals also like to have the possibility to plot weight for age in all children and adolescents. A Canadian working group has calculated and included weight percentiles on the weight for age chart for children and adolescents older than 10 years. These data are presented as a dotted line, reflecting the importance of primarily using BMI to evaluate body mass, as emphasized by the WHO.

GPED has received many requests to have these charts made widely available under the name of the country where they would be used. Thanks to Public Health Agency of Canada, Canadian group for Pediatric Endocrinology, Dietitians of Canada and with the permission from Dr Mercedes de Onis (WHO, who designed and performed the study for the WHO), this is now possible.

GPED is pleased to make growth charts based on WHO data available in French, English or Spanish with the name of your country. The figures provide examples of the chats in 3 languages and for both boys and girls.

 

Please contact Dr Jean-Pierre Chanoine, Secretary General, GPED at info@globalpedendo.org for more information.

Can CAH be effectively treated in children if hydrocortisone tablets are not available?

Your feedback is welcome and will be published in the next newsletter

The management of CAH requires administration of glucocorticoids and, when (sub)clinical salt wasting is present, fludrocortisone. None of the synthetic glucocorticoids that are presently available mimic the physiological rhythm of endogenous cortisol (early morning peak followed by a progressive decrease over 24 hours). Hydrocortisone is traditionally recommended as the first line treatment for glucocorticoid replacement in neonates and children. However, in many countries, hydrocortisone tablets are not available and other synthetic glucocorticoids need to be considered: prednisolone (PRDL), prednisone (PRED), dexamethasone (DEX) (1, 2, 3).

The greatest risk of using these more potent glucocorticoids is overtreatment, decreased height velocity and exogenous Cushing. However, when equivalence doses of 10 (HC) to 1 (PRED and PRDL) or 80-100 (DEX) to 1 (HC) are used, several authors have suggested that careful use of these more potent glucocorticoids can successfully achieve glucocorticoid replacement without side-effects.

GPED@ESPE in Vienna      

Friday September 20, 2019, 1400-1600, Room TBD

The Long Winding Road towards Sustainable Access to Affordable Insulin

Join us for an exciting symposium and round table on insulin access during the ESPE meeting in Vienna on Friday September 20, 1400-1600 PM (Room TBD)

Positions available at GPED

Elections during AGM: Sept 20 16-1700)

GPED is accepting nominations for the positions of: Secretary-General, Treasurer and Secretary: send an Email to  info@globalpedendo.org

 

WHO growth charts now available to GPED members in a new format!!

Get growth charts personalized with the name of your country

Available in English, French and Spanish

Background: Growth monitoring is the single most useful tool for defining health and nutritional status in children at both the individual and population level. In 2006, the World Health Organization (WHO) released new international growth charts depicting the growth of children from birth to age five years, who had been raised in six different countries (Brazil, Ghana, India, Norway, Oman, USA). Because the infants and children included in this study were raised under optimal conditions (including exclusive breastfeeding for the first four to six months of life), these WHO growth charts represent the best description of physiological growth for children from birth to five years of age. As such, they depict the rate of growth that should serve as a goal for all healthy infants and children, regardless of ethnicity, socioeconomic status, and type of feeding. Because of their prescriptive nature, they are growth standards. In 2007, motivated by the global surge in childhood obesity, the WHO also released charts for monitoring the growth of older children and adolescents. These reference curves were constructed using updated and improved data collected by NCHS (National Center for Health Statistics) in 1977 and linked to the WHO Child Growth Standards curves.

Context: Using the original WHO data, Canada has formatted the curves in order to obtain a design that is similar in appearance to growth charts used in many countries in the world and attractive for Canadian health professionals. The set consists in 8 growth charts (4 for boys and 4 for girls): length and weight for age (0-2 years), weight for length and head circumference (0-2 years), height and weight for age (2-19 years), BMI for age (2-19 years).

Welcome to our 2019 GPED fall newsletter!

Just in time before the European Society for Pediatric Endocrinology conference in Vienna, we are getting out this 13th issue, excited to promote the GPED symposium on sustainable access to affordable insulin. Join us for this informative and interactive session, followed by the GPED annual general meeting—see page 1 below for information on available positions.

In other news, our GPED’s secretary general Jean-Pierre Chanoine spent the past few months of his sabbatical working at the World Health Organization headquarters in Geneva during. In this issue, he presents some of his work on three projects relevant to global pediatric endocrinology.

1. Growth curves: The essential “vital sign” in endocrinology, find out how you can create specific growth charts for your country, using original WHO data and formatting by Canadian colleagues (pages 2-3). 2. Congenital adrenal hyperplasia: Join the discussion on whether and how we can adequately treat congenital adrenal hyperplasia in settings where hydrocortisone is unavailable. Do you agree? What is the practice in your country? What pro’s and con’s do you see? (page 4). 3. Congenital hyperinsulinism: There’s an important optimistic update for children, families and health care providers taking care of congenital hyperinsulinism: Diazoxide will be included on the next WHO list of essential medicines! Years of lobbying and a lengthy application to the WHO have finally paid out (page4).

Finally, our colleague Asma Deeb is pointing to current guidelines on diabetes management during Ramadan (page 5).

Enjoy the Read!!

13th Edition 

Editorial

References

1. Whittle E and Falhammar H. Glucocorticoid regimens in the treatment of congenital adrenal hyperplasia: A systematic review and meta-analysis. J Endocr Soc 2019; 3: 1227-1245

2. Rivkees SA. Dexamethasone therapy of congenital adrenal hyperplasia and the myth of the “Growth Toxic” glucocorticoid. Int J Pediatr 2010, 2010:56968 (10 pages)

3. Rivkees SA and Stephenson K. Low-dose dexamethasone therapy from infancy of virilizing congenital adrenal hyperplasia. Int J Pediatr 2009, 2009:274682 (4 pages)

4. Manchanda A, Laracy M, Savji T, Bogner RH. Stability of an alcohol-free, dye-free hydrocortisone compounded (2 mg/ml) hydrocortisone oral solution

Management of diabetes during Ramadan

Dr Asma Deeb has worked with an international group of ISPAD (International Society for Pediatric and Adolescent Diabetes) diabetes specialists on the development of pediatric and adolescent guidelines for the management of diabetes during Ramadan. In addition, Dr Deeb is a coautor on two related sister publications. The first one summarizes the views on Ramadan fasting and examines the safety of fasting and its impact on diabetes control. The second one is a survey of the perceptions and practices related to the management of diabetes during Ramadan in children and adolescents by the members of the Arab Society for Paediatric Endocrinology and Diabetes (ASPED). Together, these three publications provide a multifaceted understanding of key aspects of the impact of Ramadan on diabetes management in Muslim children and adolescents who practice Ramadan fasting. These articles are also relevant to all pediatric endocrinologists involved in the care of Muslim children and adolescents.

Overall, a wide variation in the management of children and adolescents with diabetes during Ramadan was observed in ASPED countries emphasizing the need for guidelines. The guidelines start with an explanation of the history, importance and rationale for Ramadan in the life of a Muslim. It stresses that although observing the Ramadan fast is a key aspect of religious life, patients with chronic conditions such as diabetes are exempt from this obligation.

References

Deeb A, Elbarbary N, Smart C, Beshyah SA, Habeb A, Kalra S, Al Alwan I, Babiker A, Al Amoudi R, Pulungan AB, Humayun K, Issa U, Yazid M, Sanhay R, Akanov Z, Krogvold L, de Beaufort C. ISPAD Clinical Practice Consensus Guidelines: Fasting Ramadan by young people with Diabetes. Pediatr Diabetes 2019 (in press)

Beshyah SA, Habeb AM, Deeb A, Elbarbary NS. Ramadan fasting and diabetes in adolescents and children: A narrative review. Ibnosina J Med Biomed Sci 2019 (in press)

Elbarbary N, Deeb A, Habeb A, Beshyah SA. Management of diabetes during Ramadan fasting in children and adolescents: A survey of physicians’ perceptions and practices in the Arab Society for Paediatric Endocrinology and Diabetes (ASPED) Countries. Diabetes Res Clin Pract 2019; 150: 274-281

Deeb A, Al Qahtani N, Akle M, Singh H, Assadi R, Attia S, Al Suwaidi H, Hussain T, Naglekerke N. Attitude, complications, ability of fasting and glycemic control in fasting Ramadan by children and adolescents with type 1 diabetes mellitus. Diabetes Res Clin Pract 2017; 126: 10-15

 

For information and reprints, please contact Dr Asma Deeb, Paediatric Endocrinology Department, Mafraq Hospital, Abu Dhabi & Gulf University, Ajman, UAE. Email: Adeeb@seha.ae

Editorial

11th Edition 

Happy New Year! While many of you may start to settle into 2019, the first GPED newsletter of the year is looking back at 2018, providing you with a broad range of global pediatric endocrinology highlights. We have summarized 2018’s global pediatric endocrinology related publications in this year’s European Society for Pediatric Endocrinology Yearbook, are reporting on Chile’s 2018 global pediatric endocrinology education events, are showcasing important advocacy efforts on congenital hyperinsulinism and global access to insulin, and highlighting new guidelines for newborn screening in India. In other news, in an effort to broaden the perspective on global pediatric endocrine issues, we are excited to announce the expansion of the GPED newsletter editorial team to 5 (!) additional colleagues from across the globe, spanning from Latin America, the Middle East, China and India all the way to Africa. Contributions from you, our members & readers remain more than welcome—send us your notice of events, announcements, your Op-Ed or commentaries to info@globalpedendo.org.

Newborn Screening for Congenital Hypothyroidism in India: Let’s Start!

An estimated 24 million babies are born every year in India. So far, systematic newborn screening for congenital hypothyroidism (NBS CH) has not been routinely available on a national level but the Indian Society for Pediatric and Adolescent Endocrinology (ISPAE) wants this to change. In 2018, ISPAE published two landmark papers that define the process of NBS CH in India.

#Insulin4All - the global crisis on insulin access

In 1921, almost 100 years ago, the discovery of insulin by Banting, McLeod, Best and Phillips lifted the death sentence off of type 1 diabetes (T1D). It became a treatable chronic condition for those with access to insulin. Aware of the impact, the scientists gave away any proprietary rights so that insulin could be made available to all who needed it. Fast forward to 2018, the most common cause of death for children with T1D remains lack of access to insulin.

ESPE Yearbook 2018: Global Health Highlights

Since 2016, the traditional European Society for Pediatric Endocrinology Yearbook of Pediatric Endocrinology has included a chapter on Global Health for the Pediatric Endocrinologist. The 2018 edition is no different! For the first time, the yearbook is exclusively available online at http://www.espeyearbook.org, while the global health chapter can be found at http://www.espeyearbook.org/ey/0015/ey0015.13.htm.